Hippocratic AI, the self-described “safety-first” generative AI healthcare company, has closed a $126 million Series C funding round at a $3.5 billion valuation, bringing total capital raised to $404 million.
The round was led by Avenir Growth, with participation from CapitalG (Google’s growth fund), Andreessen Horowitz (a16z), General Catalyst, Kleiner Perkins, and several marquee investors and health systems including Universal Health Services, Cincinnati Children’s Hospital, and WellSpan Health.
The raise is a resounding vote of confidence not just in Hippocratic AI’s product but in its safety-centric approach to deploying agentic AI in healthcare — an industry where precision and trust aren’t optional.
“After speaking with a significant number of customers, we believe Hippocratic AI is leading the agentic healthcare category,” said Andrew Sugrue, Co-founder of Avenir Growth. “Their relentless focus on safety has earned them the trust of healthcare organizations around the world.”
From Startup to Healthcare Powerhouse in 15 Months
In just over a year since launching commercially, Hippocratic AI has formed partnerships with more than 50 major healthcare organizations across six countries, spanning providers, payors, and pharmaceutical companies.
Its platform now supports over 1,000 clinical use cases and has completed 115 million patient interactions — with zero reported safety issues.
That safety record is no accident. The company’s agents are built around what it calls its Polaris Safety Constellation Architecture, a multi-layered framework for testing, clinical validation, and continuous monitoring — designed to make AI behavior both auditable and empathetic.
“Every call our agents make is a patient whose life we help make healthier,” said Munjal Shah, Co-founder and CEO of Hippocratic AI. “This capital allows us to touch more lives and help more people while staying true to our core values of ‘do no harm’ and ‘patients first.’”
Healthcare’s Generative AI Moment
The funding comes amid a massive AI wave in healthcare — where organizations are moving from pilot projects to production-scale deployments of generative AI assistants.
Hippocratic AI’s platform stands out for its agentic architecture: autonomous, task-specific AI agents trained for clinical, administrative, and patient communication workflows. These range from chronic condition outreach and prescription refills to claims support and post-discharge monitoring.
“Their rapid growth is a testament to the demand for solutions to our industry’s labor and patient access crisis,” said Julie Yoo, General Partner at a16z. “Hippocratic AI is solving problems that traditional automation simply can’t.”
Trusted by Healthcare’s Heavyweights
Hippocratic AI’s roster reads like a who’s who of global healthcare:
Cleveland Clinic, Northwestern Medicine, Moffitt Cancer Center, University Hospitals, Advocate Health, WellSpan Health, Cincinnati Children’s, OhioHealth, Sanford Health, and Sheba Medical Center, among others.
These organizations are using Hippocratic AI’s agents to extend access, reduce administrative burden, and improve patient engagement — all while maintaining clinical rigor.
At WellSpan Health, the AI agent — nicknamed “Anna” — has already become a trusted virtual care assistant.
“The safety information on Anna is absolutely terrific,” said Roxanna Gapstur, PhD, RN, CEO of WellSpan Health. “Our clinical leaders have been very impressed.”
At Advocate Health, Chief Digital Officer Andy Crowder emphasized that “AI should amplify human connection rather than replace it.” Hippocratic AI, he said, “focuses on real-world safety and co-development, helping us deliver empathetic, clinically safe patient interactions.”
Building a System of Abundance
Hippocratic AI’s rapid rise also speaks to a deeper industry transformation. Healthcare is facing simultaneous labor shortages, cost pressures, and access challenges — and many see safe generative AI agents as a way to deliver “healthcare abundance.”
“They are applying clinically safe, empathetic generative AI in ways that expand access and dignity in care,” said Hemant Taneja, CEO of General Catalyst, which co-created Hippocratic AI. “It’s a shining example of how Health Assurance can be realized.”
The company plans to use its new capital to scale deployments globally, invest further in safety infrastructure, and pursue strategic acquisitions to broaden its clinical and operational footprint.
Why It Matters
In a market where many generative AI startups are still chasing product-market fit, Hippocratic AI appears to have already found it — backed by top-tier investors, trusted by leading health systems, and grounded in safety data that few can match.
If 2024 was the year healthcare AI proved its potential, 2025 may be the year companies like Hippocratic show how to do it responsibly — and profitably.
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